Jump to navigation
The effects of Haskap Berry (Lonicera caerulea) extract on oxidative stress resistance
and its intergenerational inheritance in Caenorhabditis elegans
Bialas, Dr. Nathan
As superfoods gain popularity in mainstream media, investigating their potential health benefits has become an attractive area of research. Fruits such as açai berries, blueberries and strawberries contain high levels of antioxidants that have been shown to reduce the risk of diabetes, cardiovascular disease, and cognitive decline. In this study, we examined the benefits of the lesser-known haskap berry (Lonicera caerulea) on the model organism Caenorhabditis elegans. In previous years it was determined that haskap berry extract can increase lifespan and stress resistance in C. elegans via the daf-16 pathway (homologous to the FOXO pathway in mammals). In this study, the intergenerational transmission of these benefits was explored as were the downstream proteins that are affected by DAF-16. It was found that the lifespan extension benefits gained from HBE do exhibit intergenerational transmission in C. elegans. Using transgenic strains of C. elegans it was found that HBE upregulates the expression of SOD-3 and protects worms from oxidative stress. These results highlight some of the benefits of haskap berry and suggest it is a prime candidate for further study.
This poster won the Dean, Faculty of Science Award (2021) Advisor: Dr. Nathan Bialas, Department of Biology