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Investigation of the neuroprotective effects of Haskap berry (Lonicera caerulea) extract on Caenorhabditis elegans
Alzheimer’s Disease (AD) is the most common form of neurodegenerative dementia in Canada. Many researchers are investigating therapeutic options for the prevention and treatments of AD using natural plant-based sources i.e. superfoods.Haskap berries (HBs) (Fig. 1) are originally native to Siberia and northeastern Asia but have recently expanded to the Canadian market.The compounds found in HBs, such as the anthocyanin cyanidin-3-glucoside (C3G), have demonstrated in purified in vitro studies to have beneficial effects on lifespan, development, and neuronal growth. Research goals of this project are to continue previous work into the investigation of the effects of Haskap Berry Extract (HBE) on C. elegans and determine if HBE has neuroprotective effects in C. elegans, in terms of delaying the onset of phenotypic symptoms, and reducing the accumulation of Aβ plaques.
This poster won an Associate Vice-President, Research, Engagement, and Graduate Studies award (2020). Advisor: Dr. Nathan Bialas, Department of Biology.